Web Development Best Practices (Building Real-World Cloud Apps with Azure)

•Stateless web servers behind a smart load balancer.
•Avoid session state (or if you can’t avoid it, use distributed cache rather than a database).
•Use a CDN to edge-cache static file assets (images, scripts).
•Use .NET 4.5’s async support to avoid blocking calls.

http://www.asp.net/aspnet/overview/developing-apps-with-windows-azure/building-real-world-cloud-apps-with-windows-azure/web-development-best-practices